From Puebla International Airport: Access Highway Mexico - Puebla / Mexico 150D from Highway to Hermanos Serdan / Cholula Airport - Puebla. 8 min (6.7 km) Continue on Highway Mexico - Puebla / Mexico 150D towards Calle 11 Nte. on November 20, Heroica Puebla de Zaragoza. Take the exit towards Puebla Centro / Mexico 150D / Chiautempan of Autopista Mexico - Puebla / Mexico 150D. 18 min (24.0 km) Continue on Calle 11 Nte . and then take Blvrd Heroes del 5 de Mayo towards Calle 3 Ote. in the historic center of Puebla. You will find Casa Pepe Puebla immediately to the left.