From Hamburg Airport the best option is to take a taxi, it will take you only 30 minutes & the cost is approx. Euro 20,-. Alternatively you can take the underground. In this case you need to take the bus from Hamburg Airport to the main train station Hamburg. From the main train station you take the underground U3 in direction: Barmbek & get off either at the station: Feldstrasse or at the station: St. Pauli. From here it is only 3 minutes walking distance to the Hotel.